The gene of Homo sapiens contains a defective gene for the synthesis of active enzyme protein, L-gu

Irwin Stone was a chemical engineer by training, by vocation and biochemical paleopathologist for pastime. He began to work on ascorbic acid in 1934 and received the first U.S. patent for its use as a food antioxidant. The worldwide use of this process has been a factor in the virtual elimination of frank clinical scurvy in developed countries. idexx careers In 1965-67 idexx careers he published a series of articles describing the genetic disease, liver-enzyme, Hypoascorbemia and its significance in medicine. This new genetic approach provides the rationale idexx careers for the use of large doses of ascorbic acid in Orthomolecular Therapy. E 'was director of Megascorbic Research, Inc.
The gene of Homo sapiens contains a defective gene for the synthesis of active enzyme protein, L-gulonolactone oxidase (GLO). The absence of GLO in human liver blocks the normal mammalian conversion of blood sugar into ascorbate, leading to the potentially fatal "inborn error of metabolism of carbohydrates", the genetic disease, Hypoascorbemia (in the old nomenclature-scurvy). To survive, idexx careers humans need exogenous sources of ascorbate daily. The most mammals have the intact gene for the synthesis GLO and produce generous idexx careers daily amounts of the liver metabolite, ascorbate, for example, a goat weighing idexx careers 70 kg not stressed is capable of producing more than 13 grams of ascorbate daily and much more under stress ...
The recommended daily dose of 45 milligrams of ascorbate for human adults, now proposed and used by nutritionists, is grossolaname nte inadequate to restore the normal physiology of Homo Sapiens mammalian ascorbate. To correct this fully human genetic defect and banish epidemic of chronic subclinical scurvy requires daily intakes of ascorbate equivalent to, at least, the amounts synthesized from other mammals. Humans kept for a long term regime of complete correction of this birth defect show great benefits in health in the maintenance of well-being, in the treatment of disease and slowing the aging process. This can be regarded as the creation of a sub-human species new, more robust, longest, strongest, Homo sapiens ascorbicus, by means of a mutation it _inversione_ primates occurred about 60 million years ago. They discuss some of the practical benefits and pathways of future clinical research.
The gene of Homo sapiens contains several defective genes, not present in other mammals, which produce enzymatic dysfunction. Probably the most important of these defective genes, which severely limits the possibilities for our health and longevity, is the gene controlling the synthesis of the protein fegatoenzimatica, L-gulonolactone oxidase (GLO). This enzyme is the final member of a biochemical system of four enzymes, whose function in the liver is to convert glucose content in the blood in ascorbate. While the daily, which is linked to stress, large amounts (several grams) of ascorbate is common to most mammals, the daily production of ascorbate is zero between the members of the present Primate, Anthropoidea, because of ' missing enzyme. These members include the monkeys of the higher orders, the apes and Homo Sapiens (1).
The more primitive monkeys, members of the other Primates, Prosimii, carrying the intact gene for GLO and like other mammals are capable of producing their own ascorbate daily. idexx careers
Unless exogenous ascorbate is available continuously and in sufficient quantities to members idexx careers of the Suborder Anthropoidea, their survival would be limited idexx careers to no more than a few months, depending on the stressful events. Ascorbate, the reducing member of the oxidation-reduction system ascorbatodeidroascorbato, is a small simple molecule that is fundamental idexx careers in the human process. It has so many functions in modern plants and animals living that we have only touched the fringe of his knowledge. The list of functions of ascorbate is growing.
And 'likely that this molecule was intimately associated with the early development of life on our planet. Its probable main function in the forms of primordial life was to maintain optimal low oxidation-reduction potential (ORP: rH) in the living protoplasm and protect it from the increasing oxygen toxicity as a result of photosynthesis. As the primitive life forms became more complex, their daily requirements for ascorbate increased. The natural history idexx careers of ASCO