DRUG WARNING REMAINS IN FOODS drug residues washout period (substituted); The cattle must be slaugh

Unknown sedacol User Cattle: Beef Dairy Sheep: Goat Milk Feeding: Feeding Milk Chicken Eggs Meat Hindi: Eggs Meat Cat: Cat Dog: Dog Horse: Horse Fish: Fish Bees: Bees
Pharmacotherapeutic group: macrolide, atcvet Code: QJ01F 94 Tulathromyc been obtained by fermentation sedacol is a semi-synthetic macrolide antimicrobial agent. While many macrolide calendar are separated by having three amine groups. Therefore, it is located in the chemical subgroups Triamili.
Macrolides have a bacteriostatic effect manner. Bacterial ribosomal RNA to bind selectively to and inhibit protein synthesis by. Peptidyl-tRNA from the ribosome during translocation become effective by stimulating decomposition.
Pharmacokinetics Tulathromycin cattle to 2.5 mg / kg body weight, when administered subcutaneously at a dose is absorbed rapidly and in large amounts, which is highly dispersible body was observed to be slow and eliminations. sedacol Maximum concentration achieved in the plasma (Cmax) of 0.5 mg / ml and the time to reach this concentration (T max) is approximately 30 minutes. Tulathromyc concentrations in the lung homogenates were higher than plasma concentrations. Tulathromycin is observed that the accumulation of neutrophils and alveolar macrophages. Half-life in plasma (t 1/2) of 90 hours. Plasma protein at a lower rate (40%) binds. After intravenous administration the volume of distribution sedacol (Vss) 11 L / kg. Bioavailability made subcutaneous administration sedacol in cattle is about 90%.
USAGE AREA / INDICATIONS Draxxin Tulathromycin sensitive Mannheimia haemolytica, Pasteurella multocida, Haemophilus somnus and Mycoplasma bovis created by bovine respiratory disease indicated for the treatment sedacol and prevention. The presence of the disease in the herd should be established before preventive treatment.
Draxxin DOSAGE AND ADMINISTRATION The recommended dose of the solution by subcutaneous injection application form 2.5 mg / kg body weight / day (1 ml / 40 kg body weight). sedacol A dose of 300 kg during the treatment of heavy cattle should be divided to more than 7.5 ml of application. The animals should be treated early in the disease and the results should be evaluated within 48 hours after the application. Body weight of the animal prior to application to prevent overdosing or underdosing the application should be determined as accurately as possible.
Undesirable effects Draxxin the implementation subcutaneously to cattle at a short pain reaction and the injection of up to 30 days may cause permanent local swelling.
DRUG INTERACTIONS cross resistance with other macrolides product may occur. Such as macrolides and lincosamides should not be administered simultaneously with products with similar modes of action. Should not be confused with other veterinary medicines made for the drug compatibility sedacol studies.
OVERDOSE The recommended dose in cattle 3, the implementation of solid 5 and 10 led to temporary symptoms associated with pain at the injection site. These unrest has been a slight reduction in the form of head shaking and feed intake. The recommended dose of 5-6 times the area of mild cattle were detected in myocardial degeneration.
DRUG WARNING REMAINS IN FOODS drug residues washout period (substituted); The cattle must be slaughtered before 49 days after administration of the drug (substituted for beef is 49 days). Birth in lactating dairy cows and used for human consumption less than 2 months remaining heifers and cows should not be applied.
Laboratory studies conducted in rats and rabbits teratogenic, foetotoxic and maternally showed no effect. Tulathromycin the safety of beef during sedacol the period of pregnancy and lactation has not been studied. During this period, as performed by veterinarians in cattle / benefit analysis should be used depending on the risk.
ALMA is IMPLEMENTING MEASURES AND GENERAL WARNING Tulathromycin cause irritation of eye contact. If accidental eye contact when passing the eyes should be washed with clean water. Tulathromycin contact with the skin can cause sensitization. If accidental sedacol contact with the skin should be washed with soap and water. Hands should be washed after use. The accident is injected with human beings, should consult a doctor with the Prospectus and the label immediately.
STORAGE CONDITIONS V