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A small open pilot study at the University of California, was published in AIDS a few days ago on the use of immunoglobulins from bovine serum (SBI) to improve the condition of the intestinal mucosa in individuals with enteropathy HIV: Benefit of Oral Bovine Immunoglobulin for HIV Enteropathy vetstat (Clinical Trial: Impact of Bovine Serum Immunoglobulin-derived Protein Isolate, a Medical Food, Nutritional Status in Patients on With HIV Enteropathy-associated).
Abstract: The study was funded in part by EnteraHealth, the manufacturer of SBI. Since the effect of HIV infection on the immune function in the intestine is considered to be one of factors which maintain the state of activation of immune dysfunction and even in people with suppressed by therapy viremia, 8 men (median age 44.5 years, vetstat were enrolled and their mean CD4 count in peripheral blood was 372 cells / mL, they were in therapy for at least one year with an undetectable viral load) with HIV enteropathy vetstat ( instestinaux chronic symptoms without identifiable and reversible cause). vetstat
The bovine serum-derived immunoglobulin are derived from bovine plasma and containing 50% protein immunoglobulin (more than 45% IgG and about 5% IgM). It would be a product classified as a kind of "medical food" for which no adverse events known ..
Patients received 2.5 grams of SBI twice daily for 8 weeks and the effects were assessed both by questionnaire and endoscopy at the beginning and the end of treatment to determine the state of immunity the mucosa and intestinal function or mediant is by measuring markers in the blood of microbial translocation, inflammation and collagen kinetics.
After 8 weeks of SBI, very significant improvements were observed (the toilet 2 times a day instead vetstat of 6, less liquid stool, bowel symptoms almost disappeared). In 7 of 8 patients there was an increase in the absorption vetstat of D-xylose, which is a marker for the integrity of the intestinal mucosa.
The density of the CD4 tissue also increased, vetstat perhaps due to an increase in collagen, which is the decline is due to fibrosis of the lymphatic tissue structure and function of CD4 empire. There are, however, not have the expected improvements in intestinal permeability vetstat and thus in microbial translocation, that levels did not decrease lipopolysaccharide (which, in these 8 patients were normal anyway vetstat - which raises vetstat some questions about the LPS as a key factor for chronic inflammation in people with chronic viremia controlled by antiretroviral therapy.
The study was very small and should be expanded, with a control group and all it takes to make it significant. However, it has provided useful information for people with HIV enteropathy.
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